Network Meta-analysis

What is a Network Meta-analysis?

“An extension of indirect comparisons that allows the combination of direct evidence from head-to-head studies with indirect comparisons, and also the simultaneous analysis of the comparative effects of many interventions” – Cochrane Handbook

 

Examples of methodology projects conducted by our team

1. Veroniki, A. A., Straus, S. E., Ashoor, H., Stewart, L. A., Clarke, M., & Tricco, A. C. (2016). Contacting authors to retrieve individual patient data: Study protocol for a randomized controlled trial. Trials, 17(1), 138. doi: 10.1186/s13063-016-1238-z.
2. Veroniki, A. A., Straus, S. E., Fyraridis, A., & Tricco, A. C. (2016). The rank-heat plot is a novel way to present the results from a network meta-analysis including multiple outcomes. Journal of Clinical Epidemiology, 76, 193-199. doi: 10.1016/j.jclinepi.2016.02.016.
3. Veroniki, A. A., Soobiah, C., Tricco, A. C., Elliott, M. J., & Straus, S. E. (2015). Methods and characteristics of published network meta-analyses using individual patient data: Protocol for a scoping review. BMJ Open, 5(4), e007103. doi: 10.1136/bmjopen-2014-007103.

Examples of our Network Meta-analysis

1. Tricco, A. C., Thomas, S. M., Veroniki, A. A., Hamid, J. S., Cogo, E., Strifler, L., … & Straus, S. E. (2019). Quality improvement strategies to prevent falls in older adults: A systematic review and network meta-analysis. Age & Ageing, 48(3), 337-346. doi: 10.1093/ageing/afy219.
2. Tricco, A. C., Zarin, W., Cardoso, R., Veroniki, A. A., Khan, P. A., Nincic, V., … & Straus, S. E. (2018). Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: Systematic review and network meta-analysis. BMJ, 363, k4029. doi: 10.1136/bmj.k4029.
3. Tricco, A. C., Ashoor, H. M., Soobiah, C., Rios, P., Veroniki, A. A., Hamid, J. S., … & Straus, S. E. (2018). Comparative effectiveness and safety of cognitive enhancers for treating alzheimer’s disease: Systematic review and network metaanalysis. Journal of the American Geriatrics Society, 66(1), 170-178. doi: 10.1111/jgs.15069.
4. Tricco, A.C., Soobiah, C., Blondal, E., Veroniki, A.A., Khan, P.A., Vafaei, A., … & Straus, S.E. (2015). Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: A systematic review and network meta-analysis. BMC Medicine, 13(136). doi: 10.1186/s12916-015-0371-y.
5. Tricco, A. C., Ashoor, H. M., Antony, J., Beyene, J., Veroniki, A. A., Isaranuwatchai, W., … & Catherine, H. Y. (2014). Safety, effectiveness, and cost effectiveness of long acting versus intermediate acting insulin for patients with type 1 diabetes: Systematic review and network meta-analysis. BMJ, 349, g5459. doi: 10.1136/bmj.g5459.