Summary
This systematic review included adult people who inject drugs (PWID) exposed to controlled-release hydromorphone and the risk of acquiring endocarditis, hepatitis C virus, or HIV. Very few studies have examined the risk of IE, HCV, and HIV infection after exposure to controlled-release hydromorphone. Very low-quality and scant evidence suggests uncertainty around the risks of blood-borne infections, such as HCV and IE to PWID using this medication.
Project Resources
- Journal article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142404/
- Research Brief
Funded By
- This work was supported by the Canadian Institutes for Health Research/Drug Safety and Effectiveness Network (CIHR DSEN) Methods and Applications Group for Indirect Comparisons (MAGIC) grant (DMC-166263).
Principal Investigators
- Andrea Tricco
Co-Investigators
- Sharon E. Straus
Collaborators
- Ahmed M. Bayoumi
- Zachary Bouck
KTP Project Staff
- Charmalee Harris
- Areej Hazam
- Yonda Lai
- Vera Nincic
- Amanda Parker
- Fatemeh Yazdi