Comparative efficacy of interventions for aggressive and agitated behaviors in dementia: a systematic review and network meta-analysis
Watt J, Goodarzi Z, Veroniki AA, Nincic V, Khan PA, Ghassemi MM, Thompson Y, Tricco AC, Straus SE. Comparative efficacy of interventions for aggressive and agitated behaviors in dementia: a systematic review and network meta-analysis. Ann Intern Med. 2019 Nov 5;171(9):633-642. doi: 10.7326/M19-0993.
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Funder: Alberta Health Services Critical Care Strategic Clinical Network
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[ssba-buttons] [/sidebar] [sidebar-content]- This systematic review evaluated existing evidence regarding the use of pharmacologic and nonpharmacologic interventions to treat aggression and agitation in persons with dementia
- There is a lack of evidence regarding the efficacy of nonpharmacologic interventions in comparison to pharmacologic interventions
- This study explored both types of interventions to draw conclusions about what interventions dementia care partners should prioritize when treating aggression and agitation in persons with dementia
- We found that there are various nonpharmacologic interventions that can be used for treating aggression and agitation in persons with dementia in lieu of pharmacologic interventions
- Persons with dementia, clinicians, and caregivers should prioritize nonpharmacologic (e.g. exercise, massage therapy) over pharmacologic interventions (e.g. antipsychotics) for aggression and agitation given the potential harms associated with certain pharmacologic interventions
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Date : 18 May 2020