Network Meta-analysis

What is a Network Meta-analysis?

“An extension of indirect comparisons that allows the combination of direct evidence from head-to-head studies with indirect comparisons, and also the simultaneous analysis of the comparative effects of many interventions" - Cochrane Handbook


Network Meta Analysis


Examples of methodology projects conducted by our team

  1. Veroniki, A. A., Straus, S. E., Ashoor, H., Stewart, L. A., Clarke, M., & Tricco, A. C. (2016). Contacting authors to retrieve individual patient data: Study protocol for a randomized controlled trial. Trials, 17(1). doi: 10.1186/s13063-016-1238-z.
  2. Veroniki, A. A., Straus, S. E., Fyraridis, A., & Tricco, A. C. (2016). The rank-heat plot is a novel way to present the results from a network meta-analysis including multiple outcomes. Journal of Clinical Epidemiology. doi: 10.1016/j.jclinepi.2016.02.016.
  3. Veroniki, A. A., Soobiah, C., Tricco, A. C., Elliott, M. J., & Straus, S. E. (2015). Methods and characteristics of published network meta-analyses using individual patient data: Protocol for a scoping review. BMJ Open, 5(4), e007103. doi: 10.1136/bmjopen-2014-007103.


Examples of our Network Meta-analysis

  1. Tricco, A. C., Ashoor, H. M., Antony, J., Beyene, J., Veroniki, A. A., Isaranuwatchai, W., ... & Catherine, H. Y. (2014). Safety, effectiveness, and cost effectiveness of long acting versus intermediate acting insulin for patients with type 1 diabetes: Systematic review and network meta-analysis. BMJ, 349, g5459. doi: 10.1136/bmj.g5459.
  2. Tricco, A. C., Antony, J., Khan, P. A., Ghassemi, M., Hamid, J. S., Ashoor, H., ... & Hemmelgarn, B. R. (2014). Safety and effectiveness of dipeptidyl peptidase-4 inhibitors versus intermediate-acting insulin or placebo for patients with type 2 diabetes failing two oral antihyperglycaemic agents: A systematic review and network meta-analysis. BMJ Open, 4(12), e005752. doi: 10.1136/bmjopen-2014-005752.
  3. Tricco, A.C., Soobiah, C., Blondal, E., Veroniki, A.A., Khan, P.A., Vafaei, A., ... & Straus, S.E. (2015). Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: A systematic review and network meta-analysis. BMC Medicine. 13(136). doi: 10.1186/s12916-015-0371-y.