Individual Patient Data Network Meta-Analysis

    Safety, effectiveness, and cost-effectiveness of long-acting versus intermediate-acting insulin for patients with type 1 diabetes: a systematic review and individual patient data network meta-analysis

    Impact:

    • Aims to evaluate the comparative safety and effectiveness of long-acting insulin analogues (detemir/glargine) versus intermediate-acting (NPH and lente) and long-acting insulin in different subgroups of patients with type 1 diabetes
    • The individual patient data network meta-analysis (IPD NMA) results of this study will provide tailored evidence to improve existing guideline recommendations and inform decision-makers (e.g., the American and Canadian Diabetes Association, and the European Association for the Study of Diabetes) about the safety and effectiveness of these interventions

    Protocol:

    Funding:

    Canadian Institutes of Health Research (CIHR)


    Comparative effectiveness and safety of cognitive enhancers for treating Alzheimer's dementia: A systematic review and individual patient data network meta-analysis

    Impact:

    • Aims to examine the comparative effectiveness and safety of cognitive enhancers versus placebo or best supportive care by patient characteristics, such as Alzheimer’s dementia severity and sex
    • The outputs of this study will provide clinicians, patients and caregivers with tailored evidence to inform their decision-making

     Protocol: 

    Funding:

    Canadian Institutes of Health Research (CIHR)

    Category :

    Date : 26 Oct 2017