Influenza Vaccines: Efficacy of Mismatched versus Matched Vaccines

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    Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

    Tricco AC, Chit A, Soobiah C, Hallett D, Meier G, Chen MH, Tashkandi M, Bauch CT, Loeb M. Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis. BMC Med. 2013 Jun 25;11:153. doi: 10.1186/1741-7015-11-153.

     

    Funder: GlaxoSmithKline, Canada

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    • Our results can help public health officials anticipate the possible infection and complications from influenza during mismatched years
    • Estimates of protection for mismatched influenza seasons can be used by patients who are contemplating immunization
    • Results were used to inform a cost-effectiveness model on vaccination for influenza
    • Featured in >50 mass media articles
    • The live-attenuated influenza vaccine (LAIV) and trivalent inactivated vaccine (TIV) have been shown to offer benefit(s) during matched seasons, as well as mismatched seasons

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    Date : 25 Aug 2020

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