Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis
Tricco AC, Chit A, Soobiah C, Hallett D, Meier G, Chen MH, Tashkandi M, Bauch CT, Loeb M. Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis. BMC Med. 2013;11:153. DOI: 10.1186/1741-7015-11-153.
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Bottom Line:
- The live-attenuated influenza vaccine (LAIV) and trivalent inactivated vaccine (TIV) have been shown to offer benefit(s) during matched seasons, as well as mismatched seasons
Impact:
- Our results can help public health officials anticipate the possible infection and complications from influenza during mismatched years
- Estimates of protection for mismatched influenza seasons can be used by patients who are contemplating immunization
- Results were used to inform a cost-effectiveness model on vaccination for influenza
- Featured in >50 mass media articles
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Additional Resources:
Funding:
GlaxoSmithKline, Canada to St. Michael’s Hospital
Impact of H1N1 on socially disadvantaged populations: systematic review
Tricco, A. C., Lillie, E., Soobiah, C., Perrier, L., & Straus, S. E. (2012). Impact of H1N1 on socially disadvantaged populations: systematic review. PloS One, 7(6), e39437. DOI: 10.1371/journal.pone.0039437.
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Bottom Line:
- Our results suggest little difference in H1N1 burden between ethnic and non-ethnic minorities in high-income economy countries
Impact:
- Commissioned by the World Health Organization (WHO) to inform their international research agenda on influenza
Additional Resources:
Funding:
World Health Organization (WHO), Global Influenza Programme
Category : KS Projects
Date : 22 Mar 2016