Inhaled Corticosteroids and Beta-agonists for Chronic Asthma

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    Comparative safety and effectiveness of inhaled corticosteriods and beta-agonist for chronic asthma: a rapid review and network meta-analysis

    Tricco AC, Ashoor HM, Zarin W, Thomas S, Hamid J, Yazdi F, Lillie E, Kealey R, Ghassemi M, Loyman RJ. Comparative safety and effectiveness of inhaled corticosteroids and beta-agonists for chronic asthma: a rapid review and network meta-analysis. 2014.

     

    Commissioned and Funded by: Ontario Drug Policy Research Network (ODPRN) and Ontario Ministry of Health and Long-Term Care (OMHLTC)

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    • Our results can be used by patients and physicians to tailor administration of these agents
    • Commissioned by the Ontario Drug Policy Research Network to inform the listing of these agents by the Ontario Public Drug Program
    • Fixed or adjustable dose combined inhalers with low dosage ICS+LABA, medium dosage ICS+LABA, or high dosage ICS+LABA had the greatest probability of decreasing the risk of moderate to severe exacerbations
    • There were no significant differences in risk of cardiovascular disease or cardiovascular related mortality across all treatment groups

     

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    Date : 03 Sep 2020

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