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    Selective reporting bias in randomised controlled trials from two network meta-analyses: comparison of clinical trial registrations and their respective publications

    Wong EK, Lachance CC, Page MJ, Watt J, Veroniki A, Straus SE, Tricco AC. Selective reporting bias in randomised controlled trials from two network meta-analyses: comparison of clinical trial registrations and their respective publications. BMJ Open. 2019 Sep 5;9(9):e031138. doi: 10.1136/bmjopen-2019-031138.
     

    Funder: Ontario Ministry of Research, Innovation and Science Early Research Award (2015-2020)

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    • This study aims to determine if there is a difference in the frequency of overall serious adverse events (SAEs) reported in clinical trial registrations and their respective primary publications
    • This study was conducted for systematic review authors who incorporate safety data into meta-analyses and network meta-analyses
    • Nearly 20% of publications with results posted in a clinical trial registry had inconsistent reporting of serious adverse events (SAE) in the primary publication
    • Nearly 10% of the randomised trials with a prespecified primary outcome in the registry had a change in the primary outcome in the publication

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    Date : 11 Dec 2019

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