Serotonin Receptor Antagonists: Safety and Effectiveness in Chemotherapy Patients

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    Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis

    Tricco AC, Blondal E, Veroniki AA, Soobiah C, Vafaei A, Ivory J, Strifler L, Cardoso R, Reynen E, Nincic V. Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis. BMC Med. 2016 Dec 23;14(1):216. doi: 10.1186/s12916-016-0761-9.

     

    Commissioned and Funded by: Canadian Institutes of Health Research (CIHR) through the Drug Safety and Effectiveness Network (DSEN)

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    • Our results can be used by patients and physicians to tailor administration of these agents
    • Provided Health Canada with evidence on the safety and effectiveness of these agents for their decision-making
    • An assessment of the comparative safety of serotonin (5-HT3) receptor antagonists found that these agents were relatively safe, although none of the included studies evaluated active treatment with placebo for harms
    • All agents were effective in reducing the risk of nausea, vomiting, and chemotherapy-induced nausea or vomiting

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    Date : 17 Sep 2020

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