Serotonin Receptor Antagonists: Efficacy in Surgery Patients

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    Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

    Tricco AC, Soobiah C, Blondal E, Veroniki AA, Khan PA, Vafaei A, Ivory J, Strifler L, Ashoor H, MacDonald H, Reynen E, Robson R, Ho J, Ng C, Antony J, Mrklas K, Hutton B, Hemmelgarn BR, Moher D, Straus SE. Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis. BMC Med. 2015 Jun 18;13:136. doi: 10.1186/s12916-015-0371-y.

     

    Commissioned and Funded by: Canadian Institutes of Health Research (CIHR) through the Drug Safety and Effectiveness Network (DSEN)

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    • Our results can be used by patients and physicians to tailor administration of these agents
    • Provided Health Canada with evidence on the efficacy of these agents for their decision-making
    • Featured in >30 mass media articles
    • Granisetron plus dexamethasone was often the most effective agent at reducing nausea in patients undergoing surgery among the compared serotonin (5-HT3) receptor antagonists
    • The number of patients needed to treat ranged from two to five

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    Date : 17 Sep 2020

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