Network Meta-Analysis Methods

    A scoping review of indirect comparison methods and applications using individual patient data

    Veroniki AA, Straus SE, Soobiah C, Elliott MJ, Tricco AC. A scoping review of indirect comparison methods and applications using individual patient data. BMC Med Res Methodol. 2016;16:47. DOI: 10.1186/s12874-016-0146-y

    Impact:

    • Highlighted the need for improving the methodological and reporting characteristics of Individual Patient Data –NMAs, which is essential to ensure accuracy in clinical decisions.

    Protocol:

    Additional Resources:

    Funding:

    None


    NMA observational studies

    Impact:

    • Yet to be determined, as this is an ongoing project

    Funding:

    Ontario Ministry of Research and Innovation


    Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015

    Petropoulou M, Nikolakopoulou A, Veroniki AA, Rios P, Vafaei A, Zarin W, Giannatsi M, Sullivan S, Tricco AC, Chaimani A, Egger M, Salanti G. Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015. J Clin Epidemiol. 2017;82:20-8. DOI: 10.1016/j.jclinepi.2016.11.002

    Impact:

    • The study showed that the undertaking and reporting of statistical methods for NMA have significantly improved over the years past 16 years.
    • The descriptions of the structural characteristics of NMAs can be used to develop simulation studies and further develop methods in the field.

    Additional Resources:

    Funding:

    Canadian Institutes of Health Research (CIHR)


    Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review

    Zarin W, Veroniki AA, Nincic V, Vafaei A, Reynen E, Motiwala SS, Antony J, Sullivan SM, Rios P, Daly C, Ewusie J, Petropoulou M, Nikolakopoulou A, Chaimani A, Salanti G, Straus SE, Tricco AC. Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review. BMC Med. 2017;15(1):3. DOI: 10.1186/s12916-016-0764-6.

    Impact:

    • The need for improving the methodological and reporting characteristics of NMAs was identified, which is useful to facilitate decision making

    Protocol:

    • Protocol publication: Published with the manuscript

    Additional Resources:

    Funding:

    Canadian Agency for Drugs and Technologies in Health (CADTH) and Canadian Institutes of Health Research (CIHR)


    Empirical evaluation of inconsistency

    Impact:

    • Yet to be determined, as this is an ongoing project

    Funding:

    Canadian Institutes of Health Research (CIHR)


    Modelling the effects of drug dose in hierarchical network meta-analysis models: An application to Anti-VEGF

    Impact:

    • Yet to be determined, as this is an ongoing project

    Funding:

    None


    Empirical distribution of inconsistency

    Impact:

    • Yet to be determined, as this is an ongoing project

    Funding:

    Canadian Institutes of Health Research (CIHR)


    Contacting authors to retrieve individual patient data: study protocol for a randomized controlled trial

    Impact:

    • Yet to be determined, as this is an ongoing project

    Protocol: 

    Additional Resources:

    Funding:

    Dr. Areti-Angeliki Veroniki is funded by the Canadian Institutes of Health Research (CIHR) Banting Postdoctoral Fellowship Program. Dr. Sharon E. Straus is funded by a Tier 1 Canada Research Chair (CRC) in Knowledge Translation. Dr. Andrea C. Tricco is funded by a Drug Safety and Effectiveness Network (DSEN)/Canadian Institutes of Health Research (CIHR) New Investigator Award in Knowledge Synthesis.

    Category :

    Date : 30 Oct 2017