Network Meta-Analysis Methods

    Contacting authors to retrieve individual patient data: study protocol for a randomized controlled trial

    Impact:

    • Findings of our study will help customize approaches to planning and conducting individual patient data (IPD) meta-analyses, including estimation of the time needed and effective ways to collect the individual patient data (IPD)

    Protocol: 

    Additional Resources:

    Funding:

    Dr. Areti-Angeliki Veroniki is funded by the Canadian Institutes of Health Research (CIHR) Banting Postdoctoral Fellowship Program. Dr. Sharon E. Straus is funded by a Tier 1 Canada Research Chair (CRC) in Knowledge Translation. Dr. Andrea C. Tricco is funded by a Drug Safety and Effectiveness Network (DSEN)/Canadian Institutes of Health Research (CIHR) New Investigator Award in Knowledge Synthesis.


    Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review

    Zarin W, Veroniki AA, Nincic V, Vafaei A, Reynen E, Motiwala SS, Antony J, Sullivan SM, Rios P, Daly C, Ewusie J, Petropoulou M, Nikolakopoulou A, Chaimani A, Salanti G, Straus SE, Tricco AC. Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review. BMC Med. 2017;15(1):3. DOI: 10.1186/s12916-016-0764-6.

     

    Altmetric:

     

    Bottom Line:

    • This scoping review revealed several reporting deficiencies and shortcuts in knowledge synthesis methods
    • Education amongst the research community is required to improve the quality of reporting and methodological quality of published network meta-analyses (NMAs)
    • The need for improving the methodological and reporting characteristics of network meta-analyses (NMAs) was identified, which is useful to facilitate decision making

    Impact:

    • The database of network meta-analysis (NMA) characteristics generated from this review is being used for future research to advance the science of knowledge synthesis, including a recent publication comparing five knowledge synthesis approaches commonly used to assess clinical interventions

    Additional Resources:

    Funding:

    Canadian Agency for Drugs and Technologies in Health (CADTH) and Canadian Institutes of Health Research (CIHR)


    Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015

    Petropoulou M, Nikolakopoulou A, Veroniki AA, Rios P, Vafaei A, Zarin W, Giannatsi M, Sullivan S, Tricco AC, Chaimani A, Egger M, Salanti G. Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015. J Clin Epidemiol. 2017;82:20-8. DOI: 10.1016/j.jclinepi.2016.11.002

     

    Altmetric:

     

    Bottom Line:

    • The study showed that the undertaking and reporting of statistical methods for network meta-analysis have significantly improved over the past 16 years

    Impact:

    • The descriptions of the structural characteristics of network meta-analyses can be used to develop simulation studies and further develop methods in the field

    Additional Resources:

    Funding:

    Canadian Institutes of Health Research (CIHR)


    A scoping review of indirect comparison methods and applications using individual patient data

    Veroniki AA, Straus SE, Soobiah C, Elliott MJ, Tricco AC. A scoping review of indirect comparison methods and applications using individual patient data. BMC Med Res Methodol. 2016;16:47. DOI: 10.1186/s12874-016-0146-y

     

    Altmetric:

     

    Bottom Line:

    • Highlighted the need for improving the methodological and reporting characteristics of individual patient data network meta-analyses, which is essential to ensure accuracy in clinical decisions
    • One in three indirect comparison methods modeling individual patient data adjusted results from different trials to estimate effects as if they had come from the same, randomized, population
    • Key methodological and reporting elements (e.g., evaluation of consistency, existence of study protocol) were often missing from an indirect comparison papers

    Impact:

    • The methods identified in this study can be used in future individual patient data network meta-analyses

    Protocol:

    Additional Resources:

    Funding:

    None

     

    Category :

    Date : 30 Oct 2017